Cyclosporine ®
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Reviewed on Feb 18, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on February 18, 2029.
Dr Alexandra Cristina Cowell

Last updated on Feb 18, 2026.

Lowers inflammation to treat chronic dry eyes.

Cyclosporine eye drops help decrease inflammation to increase natural tear production. You’ll apply it to your eyes twice a day.

Price checker

0.05%
$164.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $164.95
    Save $0.00 each order
Cyclosporine Cyclosporine

What is Cyclosporine?

Cyclosporine eye drops help treat chronic dry eyes. It decreases inflammation to increase tear production, helping to lubricate your eyes naturally.

Your doctor will initially recommend at-home treatments for dry eyes, such as warm compresses, using a humidifier, or taking breaks from contact lenses. But if dryness persists, eye drops might then be recommended.

How does Cyclosporine work?

Cyclosporine is an immunosuppressant, meaning it reduces immune system activity. When used in the eyes, it decreases the inflammation that interferes with tear production. By reducing inflammation, it helps increase natural tear production, resulting in hydrated eyes.1

Does Cyclosporine cause side effects?

You might get side effects when using Cyclosporine, but not everyone will get them. Potential side effects include:

  • Eye pain
  • Eye irritation
  • Itchy eyes
  • Watery eyes
  • Eye redness

For those that do get them, these side effects tend to be mild and manageable. You may also experience some mild stinging or irritation when you start using Cyclosporine, but this should subside as you continue to use it. If your side effects become hard to manage, or you get severe, intense eye pain, stop using Cyclosporine and contact your doctor.

How does Restasis compare with Cyclosporine?

Restasis is the branded version of Cyclosporine. Both treatments contain the same active ingredient in the same concentration. The main differences are the packaging, manufacturing company, and price. Branded medications like Restasis are usually more expensive than generic ones.

What doses of Cyclosporine are there?

Cyclosporine comes in a single dose of 0.05%. It’s applied to your eyes twice a day, every 12 hours. Your doctor will give you more information on how long you need to use it for.

Treated trusted source:

  1. Ames, P., & Galor, A. (2015). Cyclosporine ophthalmic emulsions for the treatment of dry eye: A review of the clinical evidence. Clinical Investigation, 5(3), 267.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 18, 2026. Next review due on February 18, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Cyclosporine Cyclosporine

How to use Cyclosporine

To use Cyclosporine:

  • Wash your hands
  • Tilt your head back
  • Pull down your lower eyelid to form a pouch
  • Squeeze a drop into the pouch, taking care not to touch your eye with the tip of the dropper

Don’t use Cyclosporine while wearing contact lenses; wait at least 15 minutes before putting them in your eyes after using the medication. If possible, avoid wearing them at all while you’re using this medication to stop further dryness.

Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 18, 2026. Next review due on February 18, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Cyclosporine Cyclosporine

Cyclosporine isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

 

Cyclosporine Cyclosporine

Cyclosporine: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How effective is Cyclosporine for dry eyes?

Answer:
In a systematic review (a summary of all the existing high-quality evidence on a particular topic), it was concluded that while Cyclosporine is a widely used anti-inflammatory treatment for dry eyes, there’s not enough evidence to prove it’s significantly better than placebo or artificial tears for most patients.

The review concludes that more independent, long-term studies are needed to better understand which specific patient groups might benefit most from Cyclosporine.1

How long does Cyclosporine take to work?

Answer:
Cyclosporine doesn’t provide immediate relief, and it may take a few weeks to notice an improvement. It can also take up to six months for Cyclosporine to work best, so it's important to keep using it even if you don’t feel like it’s working.

Does Cyclosporine have any interactions?

Answer:
You should avoid using other eye drops while using Cyclosporine, or wait at least 15 minutes before using another medication. Using two medications close together can make them ineffective and increases your risk of side effects.

Let your doctor know what conditions you have or medications you’re taking so they can make sure Cyclosporine is right for you.

Can I get Cyclosporine over-the-counter?

Answer:
No, Cyclosporine is only available with a prescription from your doctor. This is so they can check if it's safe and suitable for you. Cyclosporine is an immunosuppressant, so it requires monitoring while you use it to ensure you're fine throughout the treatment.

Can I get Cyclosporine through private health insurance?

Answer:
Cyclosporine might be covered by private health insurance, but each plan can differ. It's best to check your individual plan to see if it’s covered.

If they don't cover Cyclosporine for dry eyes, you can always buy it from a private pharmacy, but you’ll have to pay out of pocket.

Treated trusted source:

  1. Pflugfelder, S. C., et al. (2019). Topical cyclosporine A therapy for dry eye syndrome. The Cochrane Database of Systematic Reviews, 2019(9), CD010051.

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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

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